CANAL-U

Statut

Directeur de Recherche 1ère classe INSERM
Docteur en Médecine
Neurologue, Ancien Interne des Hôpitaux de Paris
Docteur en Sciences de la Vie et de la Santé de l'Université Pierre et Marie Curie
Directeur du laboratoire « Transduction du signal et plasticité dans le système nerveux » Unité 536, INSERM et Université Pierre et Marie Curie

Parcours

- 1982-1985: Etudiant doctorant Chaire de Neuropharmacologie du Collège de France (Pr. Jacques Glowinski)
- 1985-1989 : Laboratory of Molecular and Cellular Neuroscience (Pr. Paul Greengard),
Université Rockefeller, New York.
- Post-Doctoral Fellow (1986-1987).
- Assistant Professor (1988-1989).
- 1990-présent : Member of the Adjunct Faculty, Université Rockefeller
- 1990-1992 : Chargé de Recherche 1ere classe INSERM, U114
- 1992-2000 : Directeur de Recherche de 2ème classe INSERM, U114
- 2000-présent : Directeur de Recherche de 1ère classe INSERM, U536

Spécialités

Intérêts scientifiques
Mes recherches actuelles concernent d'une part les mécanismes moléculaires par lesquels les neurotransmetteurs ou les neuromodulateurs, notamment la dopamine, agissent sur les neurones cibles. Nous nous intéressons plus particulièrement dans ce cadre aux réactions de phosphorylation de protéines responsables de la transduction du signal. D'autre part, nous étudions les protéines impliquées dans les contacts entre les axones et les cellules gliales myélinisantes.

Particularités

Sélection de publications récentes
- Kadare G, Toutant M, Formstecher E, Corvol JC, Carnaud M, Boutterin MC, Girault JA. PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J Biol Chem. 2003, in press
- Bonnon C, Goutebroze L, Denisenko-Nehrbass N, Girault JA, Faivre-Sarrailh C. The paranodal complex of F3/contactin and Caspr/paranodin traffics to the cell surface via a non-conventional pathway. J Biol Chem. 2003, in press
- Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D. Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol. 2003, 162:1161-72.
- Derkinderen P, Valjent E, Toutant M, Corvol JC, Enslen H, Ledent C, Trzaskos J, Caboche J, Girault JA.
Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci. 2003, 23:2371-82.
- Denisenko-Nehrbass N, Goutebroze L, Galvez T, Bonnon C, Stankoff B, Ezan P, Giovannini M, Faivre-Sarrailh C, Girault JA. Association of Caspr/paranodin with tumour suppressor schwannomin/merlin and beta1 integrin in the central nervous system. J Neurochem. 2003, 84:209-21.
- Denisenko-Nehrbass N, Oguievetskaia K, Goutebroze L, Galvez T, Yamakawa H, Ohara O, Carnaud M, Girault JA. Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres. Eur J Neurosci. 2003, 17:411-6.
- Toutant M, Costa A, Studler JM, Kadare G, Carnaud M, Girault JA. Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol Cell Biol. 2002, 22:7731-43.
- Girault JA, Peles E. Development of nodes of Ranvier.
Curr Opin Neurobiol. 2002, 12:476-85.
- Derkinderen P, Toutant M, Kadaré G, Ledent C, Parmentier M, Girault JA. Dual Role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. J Biol Chem 2001, 276:38289-38296
- Mathis C, Denisenko-Nehrbass N, Girault JA, Borrelli E. Essential role of oligodendrocytes in the formation of CNS nodal regions. Development 2001, 128:4881-4890
- Hervé D, Le Moine C, Corvol JC, Belluscio L, Ledent C, Fienberg AA, Jaber M, Studler JM, Girault JA. Gaolf levels are regulated by receptor usage, and control dopamine and adenosine action in the striatum, J Neurosci 2001 21:4390-4399.
- Faivre-Sarrailh C, Gauthier F, Denisenko-Nehrbass N, Le Bivic A, Rougon G, Girault JA. The GPI-anchored adhesion molecule F3/contactin is required for surface transport of paranodin/caspr. J Cell Biol 2000, 149:491-502.
- Girault JA, Labesse G, Mornon JP, Callebaut I. The amino termini of FAK and JAKs are divergent members of the band 4.1 family. Trends Bioch Sci 1999 24:54-57.
- Girault JA, Costa A, Derkinderen P, Studler JM, Toutant M. FAK and PYK2/CAKb in the nervous system, a link between neuronal activity, plasticity and survival? Trends Neurosci, 1999, 22:257-263.
- Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg A, Tsai LH, Kwon, YT, Girault JA, Czernik AJ, Huganir, R, Hemmings HC Jr, Nairn AC, Greengard P. Protein kinase and protein phosphatase regulation by distinct phosphorylation sites within a single molecule. Nature 1999, 402:669-671.
- Dupree JL, Girault JA, Popko B. Axo-glial interactions regulate the localization of axonal paranodal proteins. J Cell Biol 1999, 147:1145-1152.
- Fienberg AA, Hiroi N, Mermelstein PG, Song WJ, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, Ouimet CC, White FJ, Hyman SE, Surmeier DJ, Girault JA, Nestler EJ, Greengard P. DARPP-32 : regulator of the efficacy of dopaminergic neurotransmission. Science 1998, 281:838-842.
- Ait-Si-Ali S, Ramirez S, Barre FX, Dkhissi F, Magnaghi L, Girault JA, Robin P, Knibiehler M, Pritchard LL, Ducommun B, Trouche D, Harel-Bellan A. CBP histone acetyl-transferase is controlled by cycle-dependent kinases and E1A. Nature 1998, 396:184-186.
- Kwon YG, Huang HB, Desdouits F, Girault JA, Greengard P, Nairn AC. Characterization of the interaction between protein phosphatase 1 and DARPP?32 : DARPP-32 peptides antagonize the interaction of protein phosphatase 1 with binding proteins. Proc Natl Acad Sci USA, 1997, 94:3536-3541.
- Menegoz M, Gaspar P, LeBert M, Galvez T, Burgaya F, Palfrey C, Ezan P, Arnos F, Girault JA. Paranodin, a glycoprotein of neuronal paranodal membranes. Neuron, 1997, 19:319-331.
- Burgaya F, Toutant M, Studler JM, Costa A, Le Bert M, Gelman M, Girault JA. Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J Biol Chem, 1997, 272:28720-28725.
- Derkinderen P, Toutant M, Burgaya F, Le Bert M, Siciliano JC, de Franciscis V, Gelman M, Girault JA. Regulation of a neuronal form of focal adhesion kinase by anandamide. Science, 1996, 273:1719-1722.
- Siciliano JC, Toutant M, Derkinderen P, Sasaki T, Girault JA. Differential regulation of PYK2/CAKb and pp125-FAK by glutamate and depolarization in rat hippocampus. J Biol Chem, 1996, 271:28942-28946.