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LE STUDIUM Loire Valley Institute for Advanced Studies

Fondé en 1996 et inspiré des cultures historique, géographique et humaine de la Vallée de la Loire, LE STUDIUM Loire Valley Institute for Advanced Studies a pour mission de dynamiser en région Centre-Val de Loire les échanges internationaux au sein de la communauté scientifique des laboratoires de recherche publics et privés, d’accroître le potentiel de recherche et de valoriser l’excellence scientifique présente en région.
LE STUDIUM accueille des chercheurs internationaux confirmés pour des séjours de longue durée, et les met à disposition des laboratoires de la région. En parallèle, LE STUDIUM
propose une animation scientifique qui favorise les échanges transdisciplinaires et intensifie les collaborations internationales entre les équipes de recherche. Son action contribue ainsi
à la construction du capital humain pour la recherche, le développement et l’innovation en région

 

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Liste des programmes

The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine ascarid Toxocara canis do not exhibit resistance, somatic larvae have been tolerant of the macrocyclic lactones, except when used at very high concentrations. The role of drug efflux ...
To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato- Katz). However, this technique has major drawbacks resulting in a pressing need for improved diagnostic tools. By using an Ascaris-porcine infection model ...
Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs that were infected once with 10,000 A. suum eggs as well as pigs that received a trickle-infection (1,000 eggs/day, 10 days), compared ...
This presentation will provide an overview on recent investigations concerning the P-glycoprotein gene family in the equine roundworm Parascaris univalens. As prominent members of the ATP-Binding-Cassette (ABC) transmembrane transporters, Pgps are considered to play an important role in the expulsion of xenobiotic substances in many different organisms including parasitic nematodes. ...
In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to facilitate this. The intention is to prompt a discussion of what should be prioritised for future investigation and how this can be supported.  
Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and kill intestinal parasitic nematodes including Ascaris suum. Cry5B forms pores in the nematode intestines killing the parasite in less than a day. To track the time ...
The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and excretion making it a sensitive tissue for drugs to target. We used Fluo-3 AM, a calcium sensitive dye that is taken up into the cytoplasm of the ...
Toxocara canis and Toxocara cati are worldwide-distributed zoonotic intestinal helminths with frequent exposure to humans in which they can cause severe disease pathology. Upon infection, initial recognition of pathogens is mediated by pattern recognition receptors (PRRs), of which myeloid C-type lectin receptors (CLRs) recognise carbohydrate structures of bacteria, virus, fungi ...
Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of anthelmintics increases, resistance to these compounds increases. Across diverse parasitic nematode species, we will undoubtedly find treatment failures ...
Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of multiple subunits which are encoded by a large gene family, that carry multiple post-translational modifications and which exhibit varied ...
 
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