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LE STUDIUM Loire Valley Institute for Advanced Studies

Fondé en 1996 et inspiré des cultures historique, géographique et humaine de la Vallée de la Loire, LE STUDIUM Loire Valley Institute for Advanced Studies a pour mission de dynamiser en région Centre-Val de Loire les échanges internationaux au sein de la communauté scientifique des laboratoires de recherche publics et privés, d’accroître le potentiel de recherche et de valoriser l’excellence scientifique présente en région.
LE STUDIUM accueille des chercheurs internationaux confirmés pour des séjours de longue durée, et les met à disposition des laboratoires de la région. En parallèle, LE STUDIUM
propose une animation scientifique qui favorise les échanges transdisciplinaires et intensifie les collaborations internationales entre les équipes de recherche. Son action contribue ainsi
à la construction du capital humain pour la recherche, le développement et l’innovation en région

 

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Liste des programmes

The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been studied in vivo due to the lack of robust, relevant in vitro and ex vivo models mimicking the mucosal microenvironment. Various principles of ...
Pneumonia is one of the most prevalent infectious diseases worldwide, whose main cause is the pathogen Streptococcus pneumoniae. This is an opportunistic disease affecting the most to sensitive groups (infants, elderly and immunosuppressed people). In these patients the inflammatory response generated in the lungs is the main risk factor that happens in the very first days ...
The airways are colonized by a complex microbiota that varies in composition and density spatially throughout the respiratory tract, as well as temporally through the life-course.  While the lower respiratory tract has traditionally been considered sterile in healthy individuals, it is now clear that the lower airways are continuously seeded with microbiota from oral and upper ...
Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that innate immune cells do not develop immunological memory. However, over the past years this view has been challenged. A new concept has emerged, ...
Vitamin D is best known for its effects on calcium homeostasis, but a growing body of evidence shows that it also has extensive immunomodulatory actions. In this talk I will describe the effects of vitamin D metabolites on host responses to respiratory pathogens, before going on to review results of clinical trials that have ...
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo for chronic lung infections, with some antibiotics being effective in vitro but not in vivo or vice versa. We previously ...
Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio-economic burden despite annual vaccination campaigns. To help design innovative antiviral therapies, it is essential to better understand IAV-host cells interaction. In that regard, recent studies revealed ...
Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative failure. Targeting the innate immune system is an underexploited area of drug discovery for infectious diseases. The JC Sirard’s research team (Lille, Fr) has demonstrated that ...
Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and protection against re-infection is mediated largely by Th1 and Th17 cells. However the bacteria has evolved sophisticated immune subversion strategies to subvert these responses Antigen-specific regulatory T (Treg) cells that secrete IL-10 ...
Antimicrobial host defence peptides (AMPs) are effector molecules of the immune system. AMPs are considered as possible alternatives to conventional antibiotics for the treatment of respiratory infections, which is increasingly complicated by the problem of microbial antibiotic resistance. AMPs are also referred to as antimicrobial peptides and host defence peptides, and many AMPs were discovered ...
 
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