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Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 : Debate : What relevant endpoints in autonomic nerve modulation therapy trials? What kind/level of evidence? Targets to meet for approval (FDA, and in EU, beyond CE mark) and reimbursement

... should be demonstrated, as the demonstration of either one of these does not assume the other has been proven. Obviously, efferent nerve measures, the “gold standard” being reduction of renal noradrenaline (NA) spillover or less accepted alternative would...
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