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Nombre de programmes trouvés : 9385

le (29m57s)

Dr Aurélie Crabbé - Host metabolites modulate bacterial susceptibility to antibiotics

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo for chronic lung infections, with some antibiotics being effective in vitro but not in vivo or vice versa. We previously demonstrated that lung epithelial cells enhance the activity of aminoglycoside antibiotics against the opportunistic pathogen Pseudomonas aeruginosa, yet the mechanism behind was unknown. I will present mechanistic insights on how lung epithelial cells stimulate aminoglycoside activity. To ...
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le (26m1s)

Dr Mustapha Si-Tahar - Towards a metabolic anti-influenza therapy

Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio-economic burden despite annual vaccination campaigns. To help design innovative antiviral therapies, it is essential to better understand IAV-host cells interaction. In that regard, recent studies revealed the interplay between metabolic and immune signaling pathways. In this communication, I will present evidence that IAV alters lung tissues metabolism and I will show its functional consequence. Remarkably, we recently identified one metabolite that ...
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le (29m25s)

Prof. Mike Surette - The Good and the Bad of Commensal-Pathogen Interactions in the Airways

The airways are colonized by a complex microbiota that varies in composition and density spatially throughout the respiratory tract, as well as temporally through the life-course.  While the lower respiratory tract has traditionally been considered sterile in healthy individuals, it is now clear that the lower airways are continuously seeded with microbiota from oral and upper respiratory tract. This may represent a transient community that is cleared and reseeded in healthy individuals; however, it is clear that in chronic airway disease, members of this commensal microbiota thrive in the lower airways.  ...
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le (34m19s)

Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that innate immune cells do not develop immunological memory. However, over the past years this view has been challenged. A new concept has emerged, referred to as trained immunity. Upon stimulation of innate immune cells, long-term functional and epigenetic reprogramming can occur. Although the cells return to a non-activated state after the initial stimulus, they develop an enhanced secondary response to ...
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