Canal-U

Mon compte

Résultats de recherche

Nombre de programmes trouvés : 7598
Conférences

le (29m57s)

Dr Aurélie Crabbé - Host metabolites modulate bacterial susceptibility to antibiotics

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo for chronic lung infections, with some antibiotics being effective in vitro but not in vivo or vice versa. We previously demonstrated that lung epithelial cells enhance the activity of aminoglycoside antibiotics against the opportunistic pathogen Pseudomonas aeruginosa, yet the mechanism behind was unknown. I will present mechanistic insights on how lung epithelial cells stimulate aminoglycoside activity. To ...
Voir la vidéo
Conférences

le (26m1s)

Dr Mustapha Si-Tahar - Towards a metabolic anti-influenza therapy

Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio-economic burden despite annual vaccination campaigns. To help design innovative antiviral therapies, it is essential to better understand IAV-host cells interaction. In that regard, recent studies revealed the interplay between metabolic and immune signaling pathways. In this communication, I will present evidence that IAV alters lung tissues metabolism and I will show its functional consequence. Remarkably, we recently identified one metabolite that ...
Voir la vidéo
Conférences

le (29m25s)

Prof. Mike Surette - The Good and the Bad of Commensal-Pathogen Interactions in the Airways

The airways are colonized by a complex microbiota that varies in composition and density spatially throughout the respiratory tract, as well as temporally through the life-course.  While the lower respiratory tract has traditionally been considered sterile in healthy individuals, it is now clear that the lower airways are continuously seeded with microbiota from oral and upper respiratory tract. This may represent a transient community that is cleared and reseeded in healthy individuals; however, it is clear that in chronic airway disease, members of this commensal microbiota thrive in the lower airways.  ...
Voir la vidéo
Conférences

le (34m19s)

Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that innate immune cells do not develop immunological memory. However, over the past years this view has been challenged. A new concept has emerged, referred to as trained immunity. Upon stimulation of innate immune cells, long-term functional and epigenetic reprogramming can occur. Although the cells return to a non-activated state after the initial stimulus, they develop an enhanced secondary response to ...
Voir la vidéo
Conférences

le (32m27s)

Dr Antoine Guillon - Flagellin-based antibacterial strategy and clinical perspectives

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative failure. Targeting the innate immune system is an underexploited area of drug discovery for infectious diseases. The JC Sirard’s research team (Lille, Fr) has demonstrated that the respiratory tract administration of a Toll-like receptor 5 agonist (the immunomodulatory flagellin) activates innate immunity in the lung airway epithelium and enhances the therapeutic outcome (relative to low doses of antibiotic alone) in the context of ...
Voir la vidéo
Conférences

le (31m5s)

Prof. Adrian Martineau - Vitamin D in the prevention and treatment of respiratory infections

Vitamin D is best known for its effects on calcium homeostasis, but a growing body of evidence shows that it also has extensive immunomodulatory actions. In this talk I will describe the effects of vitamin D metabolites on host responses to respiratory pathogens, before going on to review results of clinical trials that have evaluated a potential role for vitamin D in the prevention and treatment of acute respiratory infections and tuberculosis. The potential for vitamin D to reduce incidence and severity of COVID-19 will also be discussed.  
Voir la vidéo
Conférences

le (27m34s)

Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in the respiratory tract

Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and protection against re-infection is mediated largely by Th1 and Th17 cells. However the bacteria has evolved sophisticated immune subversion strategies to subvert these responses Antigen-specific regulatory T (Treg) cells that secrete IL-10 are induced in the respiratory tract during B. pertussis infection and suppress protective T cell responses. Pertussis disease can be prevented in children by immunization with acellular pertussis (aP) vaccines. However, aP vaccines ...
Voir la vidéo
Conférences

le (30m35s)

Prof. Pieter Hiemstra - Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects

Antimicrobial host defence peptides (AMPs) are effector molecules of the immune system. AMPs are considered as possible alternatives to conventional antibiotics for the treatment of respiratory infections, which is increasingly complicated by the problem of microbial antibiotic resistance. AMPs are also referred to as antimicrobial peptides and host defence peptides, and many AMPs were discovered based on their antimicrobial activity against a range of micro-organisms. However, they also display other activities that are relevant for host defence, including activities related to immune modulation and wound repair. Application of AMPs (and improved ...
Voir la vidéo
Conférences

le (26m40s)

Dr Rodrigo Guabiraba - Precision cut lung slices: a novel versatile tool to examine host–pathogen interactions in the chicken lung

The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been studied in vivo due to the lack of robust, relevant in vitro and ex vivo models mimicking the mucosal microenvironment. Various principles of microbial infection including pathogen tropism, replication, spread, and innate antimicrobial host responses can readily be studied in suitable cell or tissue culture models. Precision-cut lung slices (PCLS) have the major advantages of maintaining the 3-dimensional architecture ...
Voir la vidéo

 
FMSH
 
Facebook Twitter
Mon Compte