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Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that innate immune cells do not develop immunological memory. However, over the past years this view has been challenged. A new concept has emerged, referred to as trained immunity. Upon stimulation of innate immune cells, long-term functional and epigenetic reprogramming can occur. Although the cells return to a non-activated state after the initial stimulus, they develop an enhanced secondary response to ...
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