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Nombre de programmes trouvés : 38

le (34m19s)

Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that innate immune cells do not develop immunological memory. However, over the past years this view has been challenged. A new concept has emerged, referred to as trained immunity. Upon stimulation of innate immune cells, long-term functional and epigenetic reprogramming can occur. Although the cells return to a non-activated state after the initial stimulus, they develop an enhanced secondary response to ...
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le (32m27s)

Dr Antoine Guillon - Flagellin-based antibacterial strategy and clinical perspectives

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative failure. Targeting the innate immune system is an underexploited area of drug discovery for infectious diseases. The JC Sirard’s research team (Lille, Fr) has demonstrated that the respiratory tract administration of a Toll-like receptor 5 agonist (the immunomodulatory flagellin) activates innate immunity in the lung airway epithelium and enhances the therapeutic outcome (relative to low doses of antibiotic alone) in the context of ...
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le (31m5s)

Prof. Adrian Martineau - Vitamin D in the prevention and treatment of respiratory infections

Vitamin D is best known for its effects on calcium homeostasis, but a growing body of evidence shows that it also has extensive immunomodulatory actions. In this talk I will describe the effects of vitamin D metabolites on host responses to respiratory pathogens, before going on to review results of clinical trials that have evaluated a potential role for vitamin D in the prevention and treatment of acute respiratory infections and tuberculosis. The potential for vitamin D to reduce incidence and severity of COVID-19 will also be discussed.  
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