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Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 : Debate : What relevant endpoints in autonomic nerve modulation therapy trials? What kind/level of evidence? Targets to meet for approval (FDA, and in EU, beyond CE mark) and reimbursement

... level 1 evidence.  Additionally, there are two domains of answers: a). adequate response relative to a clinical endpoint of interest, and b). adequate relative to mechanism of either efferent and/ or afferent neurologic activity reduction. Ideally, both...
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