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Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in the respiratory tract

Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and protection against re-infection is mediated largely by Th1 and Th17 cells. However the bacteria has evolved sophisticated immune subversion strategies to subvert these responses Antigen-specific regulatory T (Treg) cells that secrete IL-10 are induced in the respiratory tract during B. pertussis infection and suppress protective T cell responses. Pertussis disease can be prevented in children by immunization with acellular pertussis (aP) vaccines. However, aP vaccines ...
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