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Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 : Debate : What relevant endpoints in autonomic nerve modulation therapy trials? What kind/level of evidence? Targets to meet for approval (FDA, and in EU, beyond CE mark) and reimbursement

... be alterations of renal vein renin production or angiotensin II. Direct measurements of renal sympathetic nerve activity are also possible. Afferent nerve measures are more complicated as reductions of MSNA and total body NA spillover can each be a...
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