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Nombre de programmes trouvés : 17397
Conférences

le (54m12s)

Dessiner au hasard, c'est gagné !

Le domaine des probabilités géométriques est l’ensemble des méthodes mathématiques servant à étudier des figures géométriques dont le comportement relève du hasard. Celui-ci apparaît dès le XVIIIe siècle mais n’a réellement pris son essor que depuis 50 ans. Son développement est lié aux nombreuses applications, notamment en physique des matériaux, agronomie et astrophysique.Pierre Calka présentera à titre d’exemple le modèle classique des mosaïques aléatoires ainsi que son utilisation fondamentale dans le cadre des réseaux de télécommunications. Sans le savoir, chaque fois que nous utilisons un téléphone, nous nous servons de probabilités géométriques !
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Conférences

le (23m3s)

BRIO strategic challenges and the implementation of a translational culture in Bordeaux

About BRIO Siric challenges and actions  BRIO’s strategic objective is to strengthen Bordeaux’s leadership in Cancer Research through the creation of a dynamic cancer research community, the pursuit of scientific excellence and the establishment of state-of-the-art transversal platforms. To achieve these strategic objectives, great emphasis was placed over the last year in the consolidation of governance mechanisms conducive to an all-inclusive approach leading to a significant strengthening of relations between consortium members and local stakeholders. Capitalizing on these governance mechanisms, BRIO’s activities and financial interventions have been aligned with the ...
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Conférences

le (17m11s)

Sarcoma Database: a unique tool for research on mesenchymal tumors

Clinical biology sessionThe main sarcoma databases are the Conticabase (https://conticabase.sarcomabcb.org) and the ConticaGist (https://conticagist.sarcomabcb.org) with 18000 patients and which collect data describing patient, primary tumor, histology, molecular biology, treatment and follow-up as well as the material stored (paraffin blocks, frozen tissue, peripheral blood and cell lines). With the organization of national networks, data on practices regarding histological diagnosis and clinical management are collected in specific databases (https://rreps.sarcomabcb.org and https://netsarc.sarcomabcb.org). Currently, this database contents data from 45000 patients and will be soon merge with the Conticabase and ConticaGist. These databases allow ...
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Conférences

le (11m2s)

BRIO supporting action to integrated cancer research in Bordeaux

About BRIO Siric challenges and actions  The success of BRIO’s approach and the realization of its potential impact on the translational research community in Bordeaux rely both on the efficient delivery of research outcomes as well as on the creation of efficient, service-oriented transversal platforms. Specific tools were adapted to this purpose and implemented over the past year. Calls for proposals were launched, program management tools implemented and a specific metrology capable of facilitating the coordination of BRIO’s scientific activities developed.  To maximise the delivery of solutions developed within BRIO, ...
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Conférences

le (1h2m57s)

Flash talk - Call for proposal FAC 2014

Personalized breast cancer therapy based on viral functional assays to score pathway activityHarald Wodrich, University of Bordeaux State-of-the-art mass sequencing technology has paved the road to identify the genetic make-up of tumors on a patient-by-patient basis, allowing targeted and personalized treatment. While this worked in specific cases it remains difficult to translate genetic changes into causative cancer pathway alterations. For example, in luminal A breast tumours PIK3CA mutations that activate the kinase do not correlate with phosphorylation of downstream targets or response to PI3K inhibitors. An alternative/complementing approach is to ...
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Conférences

le (47m16s)

A new weapon against the tobacco industry : class action lawsuit using a novel epidemiologic parameter

Epidemiology and public health Lawsuits against the tobacco industry, if successful, have the potential to compensate victims of smoking and to diminish the capacity of the tobacco industry to continue to function with impunity. Up to now, the only successful legal actions against Big Tobacco have been those brought on behalf of states or provinces to recover national health care costs associated with tobacco diseases, and those brought on behalf of individual victims, in which financial damages were sought. Class action lawsuits to recover damages on behalf of the huge ...
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Conférences

le (17m30s)

How studying hematological malignancies subtypes may inform epidemiologic and clinical research

Epidemiology and public health  The aim of the talk entitled "How studying hematological malignancies (HM) subtypes may inform epidemiologic and clinical research" is to bring to the audience several examples from recent epidemiological studies showing the benefit of studying HM subtypes : 1) a population-based incidence study in France on HM identified trends in incidence for specific subtypes that help to generate etiological hypothesis, 2) An International initiative on lymphoma subtypes pooled 20 case-control studies to distangle etiological factors, 3) population-based survival study in France identifies progress in survival for ...
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Conférences

le (13m53s)

Social inequalities impacts of care management and survival in patients with non-hodgkin lymphomas

Epidemiology and public health  The principal aim of this thesis will describe the care pathway of diffuse large B cell lymphoma (DBCL) and follicular lymphoma (FL) in the general population and identify the factors predicting the place of care and survival in a population based cohort of non Hodgkin lymphoma (NHL) patients from three counties in France between 2002 and 2008. The specific aims will 1/ identify the socioeconomic and medical factors predicting the place of care (teaching vs. non teaching hospitals) and 5 years survival, 2/ identify the socioeconomic and ...
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Conférences

le (20m21s)

Modelling prognostic capabilities of tumor size : application to colorectal cancer

Epidemiology and public healthIn oncology, the international WHO and RECIST criteria have allowed the standardization of tumor response evaluation in order to identify the time of disease progression. These semi-quantitative measurements are often used as endpoints in phase II and phase III trials to study the efficacy of new therapies. However, through categorization of the continuous tumor size, information can be lost and they can be challenged by recently developed methods of modeling biomarkers in a longitudinal way. Thus, it is of interest to compare the predictive ability of cancer progressions ...
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Conférences

le (24m50s)

Life of a sample

Clinical and biological samples : opportunities and challenges for translational research  The first purpose of this talk is to provide ton non clinical researchers some main technical, ethical and reglementary issues for their access to biological samples and especially tumoral tissues which are stored  in pathology departments or tumor banks.  The second one is to explain to scientists that their project will not be successful if the sample collection is not associated with relevant clinical and biopathological annotations Finally, financial and ethical problems will be discussed as cancer biobanks ...
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