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Château de Beaulieu, 37300, Joué-Lès-Tours
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Jeanne Leblond-Chain (Intervention)
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Droit commun de la propriété intellectuelle
Citer cette ressource :
Jeanne Leblond-Chain. BTC. (2023, 20 juin). Nucleic acid aptamers for drug delivery: more than targeting agents. , in 8e Journée thématique de Biotechnocentre « Les mille et une facettes de l’ARN ». [Vidéo]. Canal-U. https://www.canal-u.tv/146765. (Consultée le 10 juin 2024)
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Nucleic acid aptamers for drug delivery: more than targeting agents.

Réalisation : 20 juin 2023 - Mise en ligne : 3 octobre 2023
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Descriptif

Aptamers are synthetic single strand DNA, RNA or modified oligonucleotides that adopt a three-dimensional structure leading to the interaction with their given target. They are discovered by Systematic Evolution of Ligands by Exponential enrichment (Selex) from a large library of sequences through iterative cycles of binding with their target and amplification. Their high affinity and specificity make aptamers valuable alternatives to antibodies, and have been explored as therapeutic agents, imaging agents, or targeting moieties. Interestingly, the nucleic acid nature of aptamers offers the possibility to program and control their structure and supramolecular assembly, opening applications in biomaterials and drug delivery. In this presentation, I will present the basics of aptamers, their most advanced applications in clinics, but also their recent development as multifunctionnal carriers in drug delivery systems.

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