Méthodes et outils pour les neurosciences

The talk showcases Computational modeling of second messenger dynamics in dendritic spines.

By combining volumetric high-resolution electron microscopy and two-photon Ca2+ imaging, we characterize astrocyte leaflets that interface with synapses and highlight the role of astrocytes as

This talk explores the ultrastructural mechanisms of synaptic plasticity in the hippocampus using serial section electron microscopy, from resource redistribution to the structural organization of

Serial electron microscopy (EM) using Focussed Ion Beam Scanning EM (FIBSEM) allowed us to assess the 3D cellular organizing principles of astrocytes at unprecedented resolution in both healthy and

Automated circuit reconstruction is a prerequisite for the analysis of connectomes.

We develop and share in open-access models, software, and 3D cell meshes to contribute to the global effort to elucidate the complex astrocyte structure-function relationship in health and disease

Integrating physiology and structure at the neuronal circuit scale can provide a mechanistic understanding on how that circuit works.