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CARON DE FROMENTEL Claude

Statut
Chargée de Recherche 1ère classe INSERM, depuis 1993.
Parcours
Stages doctoral et post-doctoral dans le laboratoire d'Oncologie Moléculaire, dirigé par le Dr Pierre May (UPR275 CNRS, IRSC, Villejuif), 1982/1989.
Affecté à l'UPR275 CNRS, 1989/1993.
Détachement auprès de la société Rhône-Poulenc Rorer, 1993/1997.
Affecté à l'U380 INSERM (ICGM, Paris), depuis 1997.
Particularités
Publications
- Caron de Fromentel C., Nardeux P.C., Soussi T., Lavialle C., Estrade S., Carloni G., Chandrasekaran K. and Cassingena R. (1985).
Epithelial HBL-100 cell line derived from the milk of an appearently healthy woman harbors SV40 genetic information. Exp. Cell Res., 160: 83-94.
- Caron de Fromentel C., Viron A., Puvion E. and May P. (1986).
SV40 large T-antigen and transformation related protein p53 are associated in situ with nuclear RNP structures containing hnRNA of transformed cells. Exp. Cell Res., 164 : 35-48.
- Caron de Fromentel C., May-Lévin F., Mouriesse H., Lemerle J., Chandrasekaran K. and May P. (1987).
Presence of circulating antibodies against the cellular protein p53 in a notable proportion of children with B cell lymphoma. Int. J. Cancer, 39 : 185-189.
- Soussi T., Caron de Fromentel C., Méchali M., May P. and Kress M. (1987).
Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53. Oncogene, 1: 71-78.
- Soudon J., Vilarem M.J., Caron de Fromentel C., Gras M.P. and Larsen C.J. (1988). Absence d'expression du gène de la protéine p53 dans une lignée humaine issue d'une leucémie de type I. C.R. Acad. Sci., 306 : 35-38.
- Soussi T., Caron de Fromentel C., Breugnot C. and May E. (1988).
Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein. Nucl. Acids Res., 16 : 11384.
- Soussi T., Caron de Fromentel C., Stürzbecher H.W., Ullrich S., Jenkins J. and May P. (1989).
Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with SV40 large T antigen and mammalian heat shock proteins 70. J. Virol., 63: 3894-3901.
- Caron de Fromentel C., Soussi T. and May P. (1990).
La protéine p53: de la biologie moléculaire à la clinique. Med. Sci., 6: 352-358.
- Soussi T., Caron de Fromentel C. and May P. (1990).
Structural aspects of the p53 protein in relation to gene evolution. Oncogene, 5: 945-952.
- Soudon J., Caron de Fromentel C., Bernard O. and Larsen C.J. (1991).
Inactivation of the p53 gene expression by a splice donor site mutation in a human T-cell leukemia cell line. Leukemia, 5: 917-920.
- Caron de Fromentel C. and Soussi T. (1992).
TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes, Chromosomes and Cancer, 4: 1-15.
- Caron de Fromentel C., Pakdel F., Chaput A., Baney C., May P. and Soussi T. (1992). Rainbow trout p53: cDNA cloning and biochemical characterization. Gene, 112: 241-245.
- Brambilla E., Gazzeri S., Moro D., Caron de Fromentel C., Gouyer V., Jacrot M. and Brambilla C. (1993).
Immunohistological study of p53 in human lung carcinomas. Am .J .Path., 143, 199-210.
- Lubin R., Schlichtholz B., Bengoufa D., Zalcman G., Trédaniel J., Hirsch A., Caron de Fromentel C., Preudhomme C., Fenaux P., Fournier G., Mangin P., Laurent-Puig P., Pelletier G., Schlumberger M., Desgrandchamps F., Le Duc A., Peyrat J.P., Janin N., Bressac B. and Soussi T. (1993).
Analysis of p53 antibodies in patients with various cancers defined B-cell epitopes of human p53: distribution on the primary structure and exposure on the protein surface. Cancer Res, 53, 5872-5876.
- Gazzeri S., Brambilla E., Caron de Fromentel C., Gouyer V., Moro D., Perron P., Berger F. and Brambilla C. (1994).
p53 genetic abnormalities and myc activation in human lung carcinoma. Int J Cancer, 58, 24-32.
- Le Goas F., May P., Ronco P. and Caron de Fromentel C. (1997).
cDNA cloning and immunological characterization of rabbit p53. Gene, 185, 169-173.
- Caron de Fromentel C., Gruel N., Venot C., Debussche L., Conseiller E., Dureuil C., Teillaud J-L., Tocqué B. and Bracco L. (1999).
Restoration of transcriptional activity of p53 mutants in human tumor cells by intracellular expression of anti-p53 single chain Fv fragments. Oncogene, 18, 551-558.
- Mary M-N., Venot C., Caron de Fromentel C., Debussche L., Conseiller E., Cochet O., Gruel N., Teillaud J-L, Schweighoffer F., Tocqué B. and Bracco L. (1999).
A tumor specific single chain antibody dependent gene expression system. Oncogene, 18, 559-564.
- Gillet R., Grimber G., Bennoun M., Caron de Fromentel C., Briand P. and Joulin V. (2000). The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents. Oncogene, 19, 3498-3507.


 
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