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Bacteria have evolved anti-phage defense systems (APDS), but little is known about how their expression is regulated during infection. Using fluorescence microscopy and RNA-Seq, our work reveals that

This study dissects the mechanisms of phage resistance in 125 clinical Pseudomonas aeruginosa isolates, revealing that while adsorption failure is the primary barrier, intrinsic bacterial defense

Biofilm-associated infections are difficult to treat due to antibiotic resistance, resulting in persistent infections and increased healthcare burdens. Phage therapy offers a promising alternative, as

This study explores prophage induction in the gut microbiota, using mice infected with Citrobacter rodentium as a model. The introduction of Escherichia coli strain DN15 suppressed C. rodentium due to

Pseudomonas aeruginosa, a Gram-negative bacterium, causes infections that are difficult to treat due to biofilm formation and antibiotic resistance. This study investigated the efficacy of two phages,

This work explores whether evolving phages on diverse bacteria make them universally effective. Directed evolution of a Tequatrovirus phage on a genetically diverse bacterial population of E. coli

Enteric viruses like noroviruses commonly contaminate shellfish and cause gastroenteritis. Due to the absence of a routine culture method for noroviruses, F-specific RNA bacteriophages (FRNAPH) are

Our study focuses on developing vials with antibiofouling coatings to prevent bacteriophage adsorption. PEG-like and zwitterion compounds are explored as promising films on glass and silicon

This study re-evaluated the mutation rate of phage lambda and its host, E. coli. It confirmed lambda's higher mutation rate but found that mismatch repair (MMR) inefficiency due to Dam methylation

This study explores the horizontal transfer of a type I-F CRISPR-Cas system from Pseudomonas aeruginosa to Pseudomonas fluorescens. While functional in the new host, its protective benefits depend on

Mycobacterium abscessus is a multidrug-resistant bacterium causing severe infections in cystic fibrosis patients, where phage therapy shows promise as an alternative treatment. Testing phages on

Evolution of a virulent Tequintavirus leads to an expansion in its host range and increases its virulence against resistant Salmonella enterica strains. Key mutations, particularly in the Long Tail