Dr Magdalena Malinowska - Grape cane extracts a natural ingredients with cosmetic activities

Modern andeffective skin care formulations based on a natural ingredients has become thekey issue in cosmetic industry. It is well known, that grapes are a rich sourceof many valuable compounds like E-resveratrol,which exhibits several biological activities for health and beauty. Wineproduction process generates various biomolecule-rich by-products includingpomace, leaves or canes. It creates an opportunity to the exploitation of thesenatural resources of metabolites in cosmetic formulations. In our studies, wefocused on the polyphenolic profiles of unique grape varieties, cultivated inthe Loire Valley in France, which over the past decades became extremely rare. Themetabolomic screening of the tested grapeextracts involved the analysis and data integration ofall the metabolites, based on high-throughput, multivariate data. Basing on theresults obtained, we evaluated the cosmetic potentialof the selected grape varieties as the multifunctional rejuvenating agents.These sources of grape metabolites exhibit various biological activitiesincluding skin whitening potential, strong antioxidant activity and thedelaying of cellular senescence. The confirmed biological effect wasadditionally supplemented with the evaluation of the bioavailability and skinpermeability of the extracts key metabolites. Importantly, the results allowedfor the initiation of in vitro cellcultures of the selected rare grape varieties for their future utilisation ininnovative skin care formulations.