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Université de Bordeaux - SAM

Self and non-self in fungi

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Self and non-self in fungi

>> Sven Saupe : Self, identity, fungi

The notion of self is a rich but ambiguous concept that is used in a wide array of academic disciplines including immunology, psychology and philosophy (in particular in different branches of phenomenology). I would like to give an introduction to the application of this concept in the description of a cell-cell interaction phenomenon occurring in many if not all filamentous fungi and designated incompatibility. The term self non-self recognition is often used to classify this phenomenon thus stressing its likeness to other biological phenomena going under the same designation such as immune recognition or gamete recognition in plant allofertilization. After giving a direct description of incompatibility, I shall describe the molecular basis of a specific case of incompatibility mechanism involving a prion protein. Time permitting I would like to use the specific example of fungal incompatibility, to attempt to illustrate my impression of the role narration and symbolism (in the form of metaphors) play in the practice of research and textual rendition of scientific results.

>> Mathieu Paoletti : Self and non-self in fungi

Fungi are engaged in various biotic interactions requiring discrimination between self and nonhet loci defining incompatibility encode proteins displaying similarities with NOD Like Receptor (NLRs) of plant and animal innate immune systems. In the model species Podospora anserina genetic interactions between incompatible alleles of het-c and het-e mediate VI. het-e encodes a NLR protein while het-c codes for a glycolipid transfer protein. Evolutionary properties of these genes lead us to hypothesize that in addition to VI their products could function as fungal immune receptors following the guard model whereby HET-e recognizes alterations of HET-c as a consequence pathogen’s action. I will describe recently developed experimental models to assess HET-c and HET-e functions in detection of and response to hetero-specific non self. I will also briefly describe the huge repertoire of NLR encoded by fungal genomes that may be involved in non self recognition in different biotic interactions.

>> Jonathan Visentin : Vegetative incompatibility in fungi looks like graft rejection in human

    Date de réalisation : 12 Janvier 2016
    Durée du programme : 77 min
    Classification Dewey : Philosophie et psychologie, Philosophie et théorie de la biologie et des sciences de la vie
    Catégorie : Conférences
    Niveau : Tous publics / hors niveau
    Disciplines : Sciences de la vie, Philosophie
    Collections : Philosophie et Biologie
    ficheLom : Voir la fiche LOM
    Auteur(s) : SAUPE Sven, PAOLETTI Mathieu, VISENTIN Jonathan
    producteur : Université de Bordeaux - Service Audiovisuel et Multimédia
    Réalisateur(s) : Université de Bordeaux - Service Audiovisuel et Multimédia
    Editeur : Université de Bordeaux - Service Audiovisuel et Multimédia
    Langue : Français, Anglais
    Mots-clés : immunologie, histocompatibilité, champignons, soi et non soi, self and non self, fungi
    Conditions d’utilisation / Copyright : Creative Commons (BY NC)


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