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Dr Peter Geldhof - Natural immunity against Ascaris – What lessons can be learned for vaccine devel…
Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on
Dr Francisco Evangelista - A bioinformatics approach to the discovery of vaccination targets in Asc…
Background: Ascariasis remains the most prevalent zoonotic helminthic disease affecting both humans and pigs and preventive chemotherapy continues to be the most widespread control method.
Dr Paul Williams - Calcium imaging of Cry5B action on the intestine of Ascaris suum
Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and
Prof. Richard Martin - Calcium imaging in the intestine of Ascaris suum, TRP channels and diethylca…
The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and
Dr Jeba Jesudoss Chelladurai - P-glycoproteins of Toxocara canis: characterization of expression an…
The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine
Sara Roose - New insights into the use of serology as a diagnostic tool for Ascaris infections in h…
To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato-
Dr Andrea Springer - Modulation of the porcine intestinal microbiome and metabolome by Ascaris suum…
Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs
Marie-Kristin Raulf - Binding of host C-type lectin receptors to Toxocara spp.-derived ligands – re…
Toxocara canis and Toxocara cati are worldwide-distributed zoonotic intestinal helminths with frequent exposure to humans in which they can cause severe disease pathology. Upon infection, initial
Prof Erik Anderson - The current scope and future perspectives of Caenorhabditis elegans as a tool …
Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of
Prof. Adrian Wolstenholme - C. elegans as a model for ascarid parasites; levamisole receptors
Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of