Dr Peter Geldhof - Natural immunity against Ascaris – What lessons can be learned for vaccine development?

Réalisation : 1 décembre 2021 Mise en ligne : 1 décembre 2021
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Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on anthelmintics. However, despite their high efficacy, the long-term benefits of anthelmintics are often disappointing because of rapid reinfections due to a highly contaminated environment. Preventing infection through vaccination would be a great advance and could result in a long-term, efficient control. The search for a vaccine against Ascaris started in the late 1970s and early 1980s with a number of experiments evaluating the protective effects of oral inoculations with UV-radiated eggs. Ever since, only about a dozen studies were performed evaluating the protective capacities of different protein mixtures or recombinant proteins, but none were able to match the levels of protection induced by administration of UV-radiated eggs. The aim of the presentation is to provide an overview of our current understanding of the immune responses occurring during natural infections and how this can help us in the development of potential vaccines against these parasites.<br>


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