Notice
Sara Roose - New insights into the use of serology as a diagnostic tool for Ascaris infections in humans
- document 1 document 2 document 3
- niveau 1 niveau 2 niveau 3
Descriptif
To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato- Katz). However, this technique has major drawbacks resulting in a pressing need for improved diagnostic tools. By using an Ascaris-porcine infection model our group has shown that detecting anti- parasite antibodies hold promise as an alternative diagnostic and is currently evaluating its potential application in humans. A first cross-sectional survey in Ethiopia showed that anti-Ascaris seroprevalence steadily increased with age providing evidence that both children and adults are continuously exposed to Ascaris. Moreover, the use of serology in the monitoring and evaluation of
MDA programs was studied; two surveys in Ethiopia and Indonesia showed that seroprevalence decreased rapidly following MDA. Recently, a longitudinal study in 4-6 years old children showed exposure from an early age onwards and a positive correlation between antibody levels and positive stool samples later on in life. To evaluate the use of serology to inform program decision making, a survey embedded in the Ethiopian national STH control program showed a correlation between prevalence based on Kato-Katz and antibody-ELISA at district level. In addition to this, research is currently also focussed on the identification of the immunogenic antigens in the Ascaris larval protein extract used in the ELISA-assays.
Thème
Dans la même collection
-
Prof Lindy Holden-Dye - Ascaris physiology and pharmacology -what next? and how?
In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to
-
Dr Jeba Jesudoss Chelladurai - P-glycoproteins of Toxocara canis: characterization of expression an…
The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine
-
Dr Paul Williams - Calcium imaging of Cry5B action on the intestine of Ascaris suum
Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and
-
Prof. Georg von Samson-Himmelstjern - Functional analysis of heterologous expression of Parascaris …
This presentation will provide an overview on recent investigations concerning the P-glycoprotein gene family in the equine roundworm Parascaris univalens. As prominent members of the ATP-Binding
-
Dr Andrea Springer - Modulation of the porcine intestinal microbiome and metabolome by Ascaris suum…
Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs
-
Prof. Richard Martin - Calcium imaging in the intestine of Ascaris suum, TRP channels and diethylca…
The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and
-
-
Dr Peter Geldhof - Natural immunity against Ascaris – What lessons can be learned for vaccine devel…
Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on
-
Dr Behdad Tarbiat -Allele frequency shift in the β-tubulin gene of Ascaridia galli in response to r…
Despite global spread of anthelmintic resistance in livestock, there has been little discussion about the development of AR in poultry. Ascaridia galli has become ubiquitous in layers due to the ban
-
Prof Erik Anderson - The current scope and future perspectives of Caenorhabditis elegans as a tool …
Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of
-
Frida Martin - Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalen…
Benzimidazole (BZ) resistance is rare in ascarids in contrast to strongyle parasites where this resistance is widespread. In strongyles, single nucleotide polymorphisms (SNPs) at codons 167, 198 and
-
Dr Francisco Evangelista - A bioinformatics approach to the discovery of vaccination targets in Asc…
Background: Ascariasis remains the most prevalent zoonotic helminthic disease affecting both humans and pigs and preventive chemotherapy continues to be the most widespread control method.
Sur le même thème
-
Dr Andrea Springer - Modulation of the porcine intestinal microbiome and metabolome by Ascaris suum…
Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs
-
Prof Lindy Holden-Dye - Ascaris physiology and pharmacology -what next? and how?
In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to
-
Prof. Richard Martin - Calcium imaging in the intestine of Ascaris suum, TRP channels and diethylca…
The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and
-
Dr JB Collins - Lack of canonical beta-tubulin resistance alleles in two benzimidazole-resistant as…
Management of nematode parasites of veterinary importance has become complicated because of the development of anthelmintic resistance. Resistance to benzimidazoles (BZ) is the most well characterized
-
Dr Peter Geldhof - Natural immunity against Ascaris – What lessons can be learned for vaccine devel…
Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on
-
-
Frida Martin - Exploring the β-tubulin gene family in a benzimidazole-resistant Parascaris univalen…
Benzimidazole (BZ) resistance is rare in ascarids in contrast to strongyle parasites where this resistance is widespread. In strongyles, single nucleotide polymorphisms (SNPs) at codons 167, 198 and
-
Prof Erik Anderson - The current scope and future perspectives of Caenorhabditis elegans as a tool …
Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of
-
Dr Francisco Evangelista - A bioinformatics approach to the discovery of vaccination targets in Asc…
Background: Ascariasis remains the most prevalent zoonotic helminthic disease affecting both humans and pigs and preventive chemotherapy continues to be the most widespread control method.
-
Dr Behdad Tarbiat -Allele frequency shift in the β-tubulin gene of Ascaridia galli in response to r…
Despite global spread of anthelmintic resistance in livestock, there has been little discussion about the development of AR in poultry. Ascaridia galli has become ubiquitous in layers due to the ban
-
Dr Friederike Ebner - Current challenges of vaccine development against Ascaris
For more than half a century, scientists have been looking for prevention strategies against Ascarids, however, we still lack fully effective vaccines to protect both humans and veterinary species.
-
Prof. Adrian Wolstenholme - C. elegans as a model for ascarid parasites; levamisole receptors
Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of
