Prof Erik Anderson - The current scope and future perspectives of Caenorhabditis elegans as a tool for ascarid research
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Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of anthelmintics increases, resistance to these compounds increases. Across diverse parasitic nematode species, we will undoubtedly find treatment failures within a short period of time, if we have not documented them already. Studies of clade V nematodes (e.g., Caenorhabditis elegans and Haemonchus contortus) have taught us that beta-tubulin alleles underlie resistance to benzimidazole (BZ) compounds, one of the most commonly used anthelmintic treatments. However, clade III nematodes, including ascarid parasites, do not have definitive data for BZ resistance or any associated resistance alleles in beta-tubulin. Using C. elegans, we have characterized the mechanisms of BZ resistance at the tissue, cell, and mechanistic level. I will present our newest unpublished results on these topics and how they can apply to ascarid parasites. Additionally, I will show our recent attempts to make a tractable ascarid parasite model to map and discover resistance alleles using poultry ascarids.
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