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Prof. Bernd Kaspers - The developing immune system of the chicken embryo
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Descriptif
Development ofhematopoietic cells has been investigated intensively in the chicken embryo.Early hematopoietic stem cells develop in the aortic region and seed to primarylymphoid organs where they mature into T- and B-lymphocytes. Subsequently, theystart to colonize the periphery at embryonic day 15/19 and around hatch,respectively. Monoclonal antibodies, recombinant cytokines and new in vivo technologies were instrumentalto dissect these pathways. For example, bursal development is dependent on Bcell activating factor of the TNF family (BAFF) as shown by retroviral mediatedoverexpression of BAFF or its decoy receptor (BCMA). This technology may beuseful to study other regulatory systems including chemokines which mediatargeted migration during haematopoiesis. Using small soluble inhibitors, werecently could show that the chemokine receptor CXCR4 and its ligand CXCL12 areessential for the colonization of the bursa anlage by B-cell precursors.Microarray studies of the developing bursa identified a range of additionalcytokines and chemokines, which may play an important role at distinctdevelopmental stages. Amongst them, we found OPG and RANKL, which have beencloned in the chicken and would be available for future studies not only inB-cell but also in bone biology. Further progress came with the first geneknockout in chickens now enabling phenotypic studies and rescue experiments tobetter understand the functional role of such factors.
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