Prof. Georg von Samson-Himmelstjern - Functional analysis of heterologous expression of Parascaris univalens P-glycoprotein in C. elegans

Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs

In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to

The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine

Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and

To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato-

The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and

Ascariasis affects nearly one billion people, predominantly in the developing world. Ascariasis also affects pigs globally and reduces production yields via decreased growth and condemnation of livers

Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of

Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on

Despite global spread of anthelmintic resistance in livestock, there has been little discussion about the development of AR in poultry. Ascaridia galli has become ubiquitous in layers due to the ban

Toxocara canis and Toxocara cati are worldwide-distributed zoonotic intestinal helminths with frequent exposure to humans in which they can cause severe disease pathology. Upon infection, initial

Benzimidazole (BZ) resistance is rare in ascarids in contrast to strongyle parasites where this resistance is widespread. In strongyles, single nucleotide polymorphisms (SNPs) at codons 167, 198 and