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Prof. Georg von Samson-Himmelstjern - Functional analysis of heterologous expression of Parascaris univalens P-glycoprotein in C. elegans
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Descriptif
This presentation will provide an overview on recent investigations concerning the P-glycoprotein gene family in the equine roundworm Parascaris univalens. As prominent members of the ATP-Binding-Cassette (ABC) transmembrane transporters, Pgps are considered to play an important role in the expulsion of xenobiotic substances in many different organisms including parasitic nematodes. Compared with the situation in mammals the genome of nematodes includes a large number of different Pgp-genes, with e.g. P. univalens exhibiting ten Pgp-genes including some apparently ascarid specific orthologues. The specific significance of these genes for instance concerning anthelmintic drug transport is thus far largely unresolved. To contribute further insight in this direction we have recombinantly expressed P. univalens Ppgs in Saccharomyces cervisiae yeasts and Caenorhabditis elegans and examined transport/efflux activities of different macrocyclic lactones. This showed for example that in nematodes both intestinal as well as transdermal ML transport can be mediated by parasite Pgp.
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