New approaches to get around roundworms
- niveau 1 niveau 2 niveau 3
- audio 1 audio 2 audio 3
- document 1 document 2 document 3

Descriptif
Parasitic roundworms, also termed ascarids, share many biological and pathological features, and so a systematic collaborative approach to the study of these offers great synergistic potential in the development of new options for controlling these infections. This group of parasites are highly prevalent and of great clinical importance in human and animals, e.g. pigs, horses, chickens, dogs and cats. Some, such as Ascaris spp. are zoonotic and it is estimated that > 800 million people are at risk of infection with Ascaris lumbricoides. To promote the advancement of science and foster international multi-disciplinary research collaborations to combat diseases caused by ascarid worms, we propose the development of an international collaboration entitled ‘The Ascarid Research and Training Initiative (ARTI)’.
To facilitate this, we will hold a scientific conference including up to five workshops dedicated to the establishment of focus working groups on specific research themes addressing the state of the art in e.g. immune response, drug action and resistance as well as genomic/transcriptomic analyses of ascarids. ARTI will include researchers working on fundamental as well as applied research issues of ascarid infections in human and animal hosts. Academic, private/industrial and governmental research institutions will be involved. Furthermore, linking the conference with a workshop on ‘Approaches and perspectives of Caenorhabditis elegans as a tool for ascarid research’ will promote technology transfer and interdisciplinary research collaborations betw. parasitologists and those working on the ‘model’ nematode species.
Read more : http://www.lestudium-ias.com/event/new-approaches-get-around-roundworms
Vidéos
In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to
Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and
The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and
The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine
To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato-
Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs
Toxocara canis and Toxocara cati are worldwide-distributed zoonotic intestinal helminths with frequent exposure to humans in which they can cause severe disease pathology. Upon infection, initial
Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of
Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of
Despite their large diversity, most of the nematode species are susceptible to broad spectrum anthelmintics. In that respect, it is tempting to speculate that extensive C. elegans data about molecular
This presentation will provide an overview on recent investigations concerning the P-glycoprotein gene family in the equine roundworm Parascaris univalens. As prominent members of the ATP-Binding
Nematodes of the genus Ascaris are important parasites of humans and swine, and related genera (Parascaris, Toxocara, and Baylisascaris) infect mammals of veterinary interest. Over the last decade,
Despite global spread of anthelmintic resistance in livestock, there has been little discussion about the development of AR in poultry. Ascaridia galli has become ubiquitous in layers due to the ban
Management of nematode parasites of veterinary importance has become complicated because of the development of anthelmintic resistance. Resistance to benzimidazoles (BZ) is the most well characterized
Ascariasis affects nearly one billion people, predominantly in the developing world. Ascariasis also affects pigs globally and reduces production yields via decreased growth and condemnation of livers
Benzimidazole (BZ) resistance is rare in ascarids in contrast to strongyle parasites where this resistance is widespread. In strongyles, single nucleotide polymorphisms (SNPs) at codons 167, 198 and
For more than half a century, scientists have been looking for prevention strategies against Ascarids, however, we still lack fully effective vaccines to protect both humans and veterinary species.
Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on
Background: Ascariasis remains the most prevalent zoonotic helminthic disease affecting both humans and pigs and preventive chemotherapy continues to be the most widespread control method. With recent