New approaches to get around roundworms

In this talk I will review the progress in providing insight into fundamental aspects of Ascaris physiology and pharmacology and the experimental approaches that have been adopted and developed to

Crystal (Cry) proteins from Bacillus thuringiensis are used as effective insecticides. These pore forming toxins act within the midgut of insects killing them. Cry5B, has been found to target and

The intestine of nematode parasites is involved in more than digestion, absorption and storage of nutrients. It is involved in vesicular trafficking, ageing, innate immunity, drug metabolism and

The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine

To monitor and evaluate mass drug administration (MDA) programs for soil-transmitted helminths (STHs) the diagnostic standard is the microscopic detection of STH specific eggs in stool smears (Kato-

Ascaris suum affects feed conversion and weight gain of pigs, but effects on intestinal microbiota remain largely unexplored. Therefore, the intestinal microbiome and metabolome was assessed in pigs

Toxocara canis and Toxocara cati are worldwide-distributed zoonotic intestinal helminths with frequent exposure to humans in which they can cause severe disease pathology. Upon infection, initial

Ascarid parasites cause a massive burden on people in the developing world and on veterinary animals worldwide. We use a limited arsenal of anthelmintics to treat these infections. As the use of

Ligand-gated ion channels provide an excellent test for any expression system and for C. elegans as a model for parasitic nematode species, including the ascarids. They are complex proteins made of

Despite their large diversity, most of the nematode species are susceptible to broad spectrum anthelmintics. In that respect, it is tempting to speculate that extensive C. elegans data about molecular

This presentation will provide an overview on recent investigations concerning the P-glycoprotein gene family in the equine roundworm Parascaris univalens. As prominent members of the ATP-Binding

Nematodes of the genus Ascaris are important parasites of humans and swine, and related genera (Parascaris, Toxocara, and Baylisascaris) infect mammals of veterinary interest. Over the last decade,

Despite global spread of anthelmintic resistance in livestock, there has been little discussion about the development of AR in poultry. Ascaridia galli has become ubiquitous in layers due to the ban

Management of nematode parasites of veterinary importance has become complicated because of the development of anthelmintic resistance. Resistance to benzimidazoles (BZ) is the most well characterized

Ascariasis affects nearly one billion people, predominantly in the developing world. Ascariasis also affects pigs globally and reduces production yields via decreased growth and condemnation of livers

Benzimidazole (BZ) resistance is rare in ascarids in contrast to strongyle parasites where this resistance is widespread. In strongyles, single nucleotide polymorphisms (SNPs) at codons 167, 198 and

For more than half a century, scientists have been looking for prevention strategies against Ascarids, however, we still lack fully effective vaccines to protect both humans and veterinary species.

Ascaris lumbricoides and A. suum are large roundworm parasites that thrives in the small intestine of humans and pigs, respectively. The control of ascariasis is currently completely reliant on

Background: Ascariasis remains the most prevalent zoonotic helminthic disease affecting both humans and pigs and preventive chemotherapy continues to be the most widespread control method. With recent