Prof. Adrian Martineau - Vitamin D in the prevention and treatment of respiratory infections

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that

Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant

The airways are colonized by a complex microbiota that varies in composition and density spatially throughout the respiratory tract, as well as temporally through the life-course.  While the lower

The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been

Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative

Pneumonia is one of the most prevalent infectious diseases worldwide, whose main cause is the pathogen Streptococcus pneumoniae. This is an opportunistic disease affecting the most to sensitive

Antimicrobial host defence peptides (AMPs) are effector molecules of the immune system. AMPs are considered as possible alternatives to conventional antibiotics for the treatment of respiratory