Dr Guido Santos - Multi-level computational modeling as a tool to understand molecular mechanisms behind bacterial lung infection

The airways are colonized by a complex microbiota that varies in composition and density spatially throughout the respiratory tract, as well as temporally through the life-course.  While the lower

Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and

Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative

The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been

Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that

Vitamin D is best known for its effects on calcium homeostasis, but a growing body of evidence shows that it also has extensive immunomodulatory actions. In this talk I will describe the effects of

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant

Antimicrobial host defence peptides (AMPs) are effector molecules of the immune system. AMPs are considered as possible alternatives to conventional antibiotics for the treatment of respiratory