Prof. Mike Surette - The Good and the Bad of Commensal-Pathogen Interactions in the Airways
- document 1 document 2 document 3
- niveau 1 niveau 2 niveau 3
- audio 1 audio 2 audio 3
The airways arecolonized by a complex microbiota that varies in composition and density spatiallythroughout the respiratory tract, as well as temporally through the life-course. While the lower respiratory tract hastraditionally been considered sterile in healthy individuals, it is now clearthat the lower airways are continuously seeded with microbiota from oral andupper respiratory tract. This may represent a transient community that iscleared and reseeded in healthy individuals; however, it is clear that inchronic airway disease, members of this commensal microbiota thrive in thelower airways. Here they are often inthe presence of the pathogens traditionally associated with chronic lunginfections. These may simply representopportunistic colonizers with little contribution to disease, or they maycontribute to disease as part of polymicrobial infections, or more directly aspathogens themselves. The pathogenicpotential of many commensal microbiota is under appreciated. Conversely, the commensal microbiota plays anintegral role in colonization resistance, and the ability of commensalmicrobiota to inhibit the growth of common pathogens is widespread. The dichotomy in ‘good vs bad’ behaviour ofcommensal microbiota is often a ‘strain’ rather than species specificproperty. While the complexity of thesecommensal-pathogen Interactions pose a challenge in standard diagnostic andmicrobiome profiling approaches to respiratory disease, they do represent opportunitiesfor novel interventions in managing chronic airway disease and reducingsusceptibility to respiratory infections in vulnerable populations.
Dans la même collection
Conférence00:27:33Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in th…
Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and
Conférence00:32:26Dr Antoine Guillon - Flagellin-based antibacterial strategy and clinical perspectives
Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance and the curative
Conférence00:34:18Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy
Innate immune cells form a vital first line of defense against pathogens, and their activation upon recognition of pathogens is rapid and non-specific. For a long time it has been assumed that
Conférence00:26:00Dr Mustapha Si-Tahar - Towards a metabolic anti-influenza therapy
Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease, which is associated with high morbidity and mortality. This virus also causes a considerable socio
Conférence00:29:56Dr Aurélie Crabbé - Host metabolites modulate bacterial susceptibility to antibiotics
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant
Conférence00:31:04Prof. Adrian Martineau - Vitamin D in the prevention and treatment of respiratory infections
Vitamin D is best known for its effects on calcium homeostasis, but a growing body of evidence shows that it also has extensive immunomodulatory actions. In this talk I will describe the effects of
Conférence00:30:07Dr Guido Santos - Multi-level computational modeling as a tool to understand molecular mechanisms b…
Pneumonia is one of the most prevalent infectious diseases worldwide, whose main cause is the pathogen Streptococcus pneumoniae. This is an opportunistic disease affecting the most to sensitive
Conférence00:26:39Dr Rodrigo Guabiraba - Precision cut lung slices: a novel versatile tool to examine host–pathogen i…
The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been
Conférence00:30:34Prof. Pieter Hiemstra - Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Transla…
Antimicrobial host defence peptides (AMPs) are effector molecules of the immune system. AMPs are considered as possible alternatives to conventional antibiotics for the treatment of respiratory
Sur le même thème
Conférence00:33:42Dr Lori L. Isom - Dancing to a different tune: TANGO offers a precision medicine approach to treati…
Dravet syndrome is an intractable developmental and epileptic encephalopathy caused largely by de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium channel α subunit
Conférence00:29:43Prof. Michelle L. Hastings - Antisense Oligonucleotides for the Treatment of Disease
Antisense oligonucleotides (ASOs) have proven to be an effective therapeutic platform for the treatment of disease.
Conférence00:28:55Dr Ana Cristina Calvo - Peripheral RNA Biomarkers in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of unknown origin that causes progressive muscle paralysis and motor neuron death.
Conférence00:30:35Prof. Antonella Riccio - RNA metabolism in developing neurons
Neurons are cells with a complex morphology, which maintain their cellular structure through the compartmentalized expression of proteins essential for growth and plasticity.
Conférence00:16:47Dr Débora Lanznaster - Combined Metabolomics and targeted-transcriptomics analysis in the muscle of…
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons, leading to paralysis and death of patients after 3-5 years of symptoms’ onset
Conférence00:28:47Director Jason Potter - What matters for making highly expressed mRNA.
The need for high quality mRNA for therapeutic applications has grown substantially over the last few years due to the efficacy of the COVID mRNA vaccines.
Conférence00:33:23Dr Horacio Cabral - RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery
Messenger RNA (mRNA) therapeutics are attracting much attention, particularly after the approval of two mRNA vaccine formulations for COVID-19.
Conférence00:40:05Prof. Krzystof Sobczak - Compounds which alleviate the pleiotropic toxicity of RNA harboring expand…
Fragile X-associated tremor/ataxia syndrome (FXTAS) is an incurable neurodegenerative disorder caused by expansion of CGG repeats in the FMR1 5'UTR.
Conférence00:32:42Prof. Steven Dowdy - Delivery of RNA Therapeutics: The Great Endosomal Escape!
All macromolecular therapeutics, including ASOs, siRNAs, peptides, proteins, CRISPR, mRNA and non-viral DNA vectors, are taken up into cells by endocytosis.
Conférence00:21:56Dr Liliane Massade - Squalenoyl siRNA PMP22 nanoparticles, a potent therapy for Charcot-Marie-Tooth…
Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication in chromosome 17, results in peripheral myelin protein 22 (Pmp22) over-expression and axon demyelination.
Conférence00:34:52Prof. Jernej Ule - How do protein-RNA condensates form and contribute to disease?
Mutations in many genes encoding RNA-binding proteins (RBPs) cause neurologic diseases, and especially the amyotrophic lateral sclerosis (ALS).
Conférence00:34:29Prof. Stefano Gustincich - Antisense long non-coding SINEUP RNAs: from molecular mechanism to thera…
Natural SINEUPs are antisense long non-coding RNAs that enhance translation of sense mRNAs. Their activity depends on the combination of two domains: the overlapping region, or binding domain (BD),