Dr Raphaël Duivenvoorden - Trained Immunity as a novel therapeutic strategy

Durée : 00:34:18 -Réalisation : 25 septembre 2020 -Mise en ligne : 25 septembre 2020
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Innate immunecells form a vital first line of defense against pathogens, and theiractivation upon recognition of pathogens is rapid and non-specific. For a longtime it has been assumed that innate immune cells do not develop immunologicalmemory. However, over the past years this view has been challenged. A newconcept has emerged, referred to as trained immunity. Upon stimulation ofinnate immune cells, long-term functional and epigenetic reprogramming canoccur. Although the cells return to a non-activated state after the initialstimulus, they develop an enhanced secondary response to a subsequentnon-specific stimulus. This shows that the innate immune system exhibitsadaptive characteristics, which may have evolved to provide greater protection againstreinfection. In this presentation we will reflect on the concept and underlyingimmunological mechanisms of trained immunity and discuss how trained immunitycan be utilized as a therapeutic strategy to prevent infection and potentiallytreat other immune related diseases.



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