Prof. Pieter Hiemstra - Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects

Réalisation : 24 septembre 2020 Mise en ligne : 24 septembre 2020
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Antimicrobial host defence peptides (AMPs) areeffector molecules of the immune system. AMPs are considered as possiblealternatives to conventional antibiotics for the treatment of respiratoryinfections, which is increasingly complicated by the problem of microbialantibiotic resistance. AMPs are also referred to as antimicrobial peptides andhost defence peptides, and many AMPs were discovered based on theirantimicrobial activity against a range of micro-organisms. However, they alsodisplay other activities that are relevant for host defence, includingactivities related to immune modulation and wound repair. Application of AMPs (andimproved substitutes of these peptides) as a treatment for respiratoryinfections has been studied for some time, but they have not yet beenintroduced into the clinic. Direct administration of AMPs is complicated by e.g.cost of production and short half-life, and alternative strategies areconsidered. These include enhancement of their local production and activity. Nevertheless,there are a number of properties that make these peptides attractive candidates,including their broad-spectrum antimicrobial activity (possibly also includinganti-SARS-CoV-2 activity), activity against multidrug resistantmicro-organisms, and wide range of activities. In this presentation, recentdevelopments in research on the role of these peptides in the lung, as well as theirclinical use in novel therapies will be discussed.


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